Even though confinement measures implemented in everywhere in the world seem to be more or less effective in the fight against the propagation of the coronavirus, the number of people infected by COVID-19 in the rest of the world keeps on rising. So, to face this world’s health crisis, searchers and health professionals have been working hard to try and find an effective medication to erase COVID-19. If the vaccine may not be used for several months, clinical trials are currently carried out in some places of the globe to complete the anti-Covid arsenal.
Dexamethasone, Interferon alpha-2b, Molnupiravir, monoclonal antibodies, Calquence... As many treatments doctors from all around the world test on patients at different stage of the disease within clinical trials. And if you do not know where to start with all these tests and vaccine prototypes, we give you a list of treatments and vaccines currently studied to have a big picture of the current research works.
Vaccines studied in the world:
Vaccination in France: How many people are vaccinated as of Thursday 15 April 2021
How many people have been given the first dose of Covid-19 vaccine in France? What are the regions vaccinating the most? This Thursday 15 April 2021, here are how many people have been given the first dose, and been fully vaccinated in France since December 27, 2020. Keep reading to find out more about the number of people vaccinated per region.
Vaccine in the world as of Friday 16 April 2021: the percentage of people vaccinated by country?
As many countries have started to vaccinate people against coronavirus in late 2020, what is the percentage of people vaccinated in comparison with the total number of inhabitants in each country? Sortiraparis delivers a daily report on the vaccine situation in the world. Here are the latest data as of Friday 16 April 2021.
Covid: Pfizer vaccine less effective against the South African variant, a study finds
Pfizer covid vaccine is said to be less effective against the South African variant... This is at least what an Israeli study found on the matter, stating this strain is likely to "break through" the vaccine. The study shifts focus of the results from the previous study carried out by the American laboratory, explaining their vaccine was working for at least six months against all variants, and especially the South African strain.
Covid: the time period between Pfizer and Moderna vaccine doses will be extended to 42 days
Olivier Véran announced in an interview with Journal du Dimanche that the time period between the two doses of vaccine will be extended to 42 days for patients given the Pfizer or Moderna vaccine.
Covid: Valneva vaccine soon to initiate phase 3 of clinical trials
This past late January, French-Austrian laboratory Valvena has announced they have launched the production of their own Covid vaccine, as it has not even completed the clinical trials yet. A leap of faith in order to improve shipping timeline, because the United-Kingdom already order 190 million doses. Currently completing phase 2, the clinical trial seems conclusive and might start phase three by the end of April.
Pfizer: France has launched the vaccine production in the country
According to news from our peers from Journal du Dimanche, the manufacturing of the Pfizer/BioNTech vaccine is to begin in France, at Delpharm, an expert in packing pharmaceutical product, starting Wednesday April 7. This is the very first Covid vaccine produced in France. In all 250 million doses are to be issued by the end of the year, according to Industry Minister Agnès Pannier-Runacher.
AstraZeneca vaccine particularly effective in people aged 65+, a Scottish study finds
Is AstraZeneca vaccine effective against severe Covid in elderly people? This is what a study carried out by the Edinburgh and Glasgow universities found, only available in preprint and currently studied to be published. If approved by a scientific committee, this observation could be a game changer for the French vaccination strategy.
Johnson & Johnson vaccine to be delivered to France sooner than expected
As Johnson & Johnson vaccine has been delivered earlier than expected, on April 12 instead of June, the day after, on Tuesday April 13, the laboratory announced they were delaying its deployment on the Old Continent because of suspicious cases of thrombosis reported to the FDA who initiated an investigation.
Covid: Sanofi’s second vaccine initiate human clinical trial
Is Sanofi catching up the race for vaccine? Even though they are still far behind, the French laboratory announced this Friday March 12 they are launching the first human clinical trials of their vaccine developed in partnership with American biotech Translate Bio.
Covid: Institut Pasteur to stop developing their main vaccine, as results are not forthcoming
Bad news in the fight against Covid! Institut Pasteur has announced they are stopping the development of their main vaccine project - currently completing clinical trial - as results are not forthcoming. A vaccine that was yet tested in humans this summer and that yet had encouraging results.
Covid: the second dose of the vaccine to be given in France 3 to 4 weeks later, as planned
This Saturday January 23, to face tensions rising from the Covid vaccine distribution around the world, the Haute Autorité de Santé has announced in a release they are recommending to defer the second dose of vaccine for 42 days, namely six weeks instead of four. A recommendation Health Minister Olivier Véran has decided not to comply with, as he would rather bet on safety. The second dose will be inoculated 28 days after the first injection, as initially decided.
Covid vaccine: a “light” version of Russian Sputnik vaccine to be issued soon?
Russian coronavirus vaccine soon to issue a lighter version? This is what the Russian authorities announced on Monday January 11, 2021 saying that only one dose of Sputnik V could be enough to protect people vaccinated. The goal? Bringing a “temporary” solution to countries the most hit by the pandemic and enable to eradicate the spread of the virus quicker.
Covid: German vaccine CureVac will be developed by Bayer too
The research for covid vaccine goes on… This Thursday January 7, pharmaceutical and agrochemical group Bayer announced they signed a partnership with laboratory CureVac to develop the ongoing vaccine. A vaccine that entered on December 14 the third clinical trial phase.
Covid: Sanofi and GSK vaccine to be ready by late 2021
Sanofi laboratory has announced their Covid vaccine will be ready for late 2021, that is to say three to four months later because of results not as good as expected during the second phase of the clinical trials.
Covid: Nanocovax, the Vietnamese vaccine to start human testing
As many Covid vaccines are already being issued, Vietnam is just starting human testing his product developed by laboratory Nanogen, Nanocovax.
Pfizer and BioNTech are making powdered vaccines to get round the refrigeration constraint
A few days ago already Pfizer and BioNTech announced their vaccines against coronavirus were over 95% effective! The only flaw is that these two products are to be stored at minus 80 degrees Celsius (-112°F), leading to logistical issues. Both laboratories are working on a powdered version to get round the problem.
Coronavirus: Ose Immunotherapeutics vaccine delivers encouraging results
French laboratory Ose Immunotherapeutics has released encouraging results as for candidate vaccine against coronavirus, adding they will initiate the clinical phase in the first quarter of the year 2021.
Treatments under clinical trial:
Covid: Pfizer to develop two treatments against the virus
Two treatments against Covid are being studied, but have delivered encouraging primary results… This is what Pfizer France director David Lepoittevin announced this Friday April 9, stating that one of them was to be given orally, the other one intravenously. Two medicines that – if trials show effectiveness – could complete the existing arsenal amid the fight against coronavirus.
Covid: take a stock on Molnupiravir, drugmaker Merck’s promising therapy against the virus
Good news amid the fight against Covid! Drugmakers Merck and Ridgeback Bio have announced their molnupiravir therapy against the virus led to promising results. The therapy is said to significatively reduced patients’ viral load. A medication given orally and currently completing clinical trials.
Covid: France has approved two monoclonal antibody therapies
This Monday March 15, the Agence du Médicament (French Medicines Agency) announced that two monoclonal antibody therapies, namely REGN-COV2 and Eli Lilly laboratory's therapy based on bamlanivimab and etesevimab were now approved in France.
Institut Pasteur Lille's promising treatment clinical trials delyed by the Minister
And what if the cure against coronavirus already exists? In September 2020, searchers from Lille Institut Pasteur discovered the existence of a molecule potentially active against the virus and, in all likelihood, not leading to side effects. Promising trials likely to soon start in human.
Covid: Eli Lilly antibody therapy said to reduce hospitalization risks, a study finds
As the race for Covid vaccines and therapies is speeding up all over the world, drugmaker Eli Lilly announced this Wednesday March 10 their antibody therapy mixing Bamlanivimab and Etsesevimab is said to reduced by 87% hospitalization and death risk in the event of severe infection. A combined therapy that received emergency use authorization back to late February from the Food & Drug Administration.
Covid: Is Colchicine a promising treatment against the virus?
According to a study carried out by Montreal Heart Institute, Colchicine – a medicine usually used to cure gout – is said to be effective against Coronavirus, according to results from a clinical trial conducted in March 2020. But results should be taken with a pinch of salt as they are not available to be peer-reviewed by the scientific community excluding 329 patients in the 4,488 raising serious questions.
Covid: Xav-19, the French antibody-based treatment undergoing clinical trials
And what if, amid the fight against Covid, one could rely – in addition to the upcoming vaccine – on antibody-based treatments? After Bamlanivimab – the treatment developed by the Eli Lilly laboratory – or even Regeneron, this is now French Nantes-based laboratory Xenothera’s turn to present a treatment undergoing clinical trials, Xav-19. A treatment that could be issued from Spring 2021.
Covid-19: Calquence, an effective treatment against cytokine shocks?
Is Claquence an effective treatment to fight against Covid-19? Pharmaceutical group AstraZeneca has announced phase 2 of their clinical trials with this potential treatment to coronavirus “did not meet the primary endpoint”. A clinical trial which point was to try and assess its effect against cytokine shocks, this violent inflammatory response from the immune system, combined with Covid-19 infection.
Coronavirus: some steroids effective against severe Covid-19, three new studies say
Are some steroids effective against severe Covid-19? This is the conclusion three studies found published in the Journal of the American Medical Association. Their effectiveness led the WHO to authorize their use for cases concerned.
Coronavirus: Kevzara underperforming as a cure to the virus, Sanofi says
This Tuesday September 1, Sanofi said they were ending their clinical trial on Kevzara as a cure against coronavirus, after noting results of this study were inconclusive.
Coronavirus: “Positive results” for the remdesivir/diltiazem treatment the Inserm says
Searchers from the French National Institute for Health and Medical Research (Inserm) in Lyon showed that mixing two medicines, remdesivir and diltiazem, gave “positive results” for a pre-clinical phase. A new step for the discovery of an effective treatment against coronavirus.
Coronavirus: chloroquine use subject to a control
Currently into lockdown in France, the medical staff keeps fighting against coronavirus, and a cure based on chloroquine is at the heart of the debate. This Monday March 23rd, 2020, Olivier Véran announces to supervise the medication as a cure to Covid-19.
Coronavirus: the European Union allows putting Remdesivir on the market
Remdesivir is at the heart of research against coronavirus and has been adopted in the United-States in early May. The European Union is now validating the authorization to put the treatment on the market.
Coronavirus: the lopinavir/ritonavir cocktail ineffective, the Recovery trail says
Is the lopinavir/ritonavir blend to fight against coronavirus ineffective? This is what several leaders of the Recovery trial say.
Covid: Interferon Alpha-2b, a promising therapy soon to be used in France?
Is interferon alpha-2b effective to fight against Covid? This is what a study found as it focused on the antiviral and has been released this May 15, 2020 in Frontiers in Immunology. A therapy first used against Hepatitis C, dengue, and even some cancers, specifically in South America, and enabling to dramatically improve coronavirus patient’s states of health.
Coronavirus: does chlorpromazine, medication against bipolarity, protect against COVID-19?
Medication against bipolarity, chlorpromazine could protect yourself against coronavirus. According to the Sainte-Anne University Hospital, patients treated with chlorpromazine are less hit by COVID-19 and symptomatic cases are rare. The Institut Pasteur has just launched a study.
Coronavirus: Anakinra, a promising treatment?
Is Anakinra an effective treatment against coronavirus? According to a French study released in The Lancet, the medicine usually prescribed for rheumatic diseases released encouraging results on severe Covid-19 forms. First results that will have to be confirmed on a greater number of patients.
Tocilizumab, the covid treatment to dramatically reduce deaths, Recovery says
This Thursday February 11, the Oxford University released the results of Recovery clinical trial on Tocilizumab, a medication generally used in rheumatology, but here, it is used to lower the number of Covid patients in ICU. And results are particularly encouraging, echoing the study led in April 2020 by AP-HP. Here is more on the matter.
Coronavirus: interferon beta, an effective treatment soon to be used in France?
According to the pharmaceutical company Synairgen, clinical trials about a treatment based on interferon beta – usually used against sclerosis – gave “very significative” outcomes against coronavirus. A treatment that could relieve severe cases with respiratory distress.
Coronavirus: are plasma transfusions effective against the disease?
Is plasma transfusion an effective solution against Covid? This is one of the ongoing study topic as to cure coronavirus and it seems to deliver rather mixed results, despite an encouraging Chinese study released in April 2020. Here is more on the matter.